Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

BACKGROUND: Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K–Akt–mTOR signaling, which is frequently dysregulated in tumors and critical for tumor...

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Detalles Bibliográficos
Autores principales: Li, Xiaoli, Zhu, Guangbei, Yao, Xintong, Wang, Ning, Hu, Ronghui, Kong, Qingxin, Zhou, Duanfang, Long, Liangyuan, Cai, Jiali, Zhou, Weiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
https://www.ncbi.nlm.nih.gov/pubmed/30588010
http://dx.doi.org/10.2147/OTT.S187315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
https://www.ncbi.nlm.nih.gov/pubmed/30588010
http://dx.doi.org/10.2147/OTT.S187315

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