CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the membrane barrier remains unclear. Here we use electron cryo-microscop...

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Detalles Bibliográficos
Autores principales: Menny, Anaïs, Serna, Marina, Boyd, Courtney M., Gardner, Scott, Joseph, Agnel Praveen, Morgan, B. Paul, Topf, Maya, Brooks, Nicholas J., Bubeck, Doryen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294249/
https://www.ncbi.nlm.nih.gov/pubmed/30552328
http://dx.doi.org/10.1038/s41467-018-07653-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294249/
https://www.ncbi.nlm.nih.gov/pubmed/30552328
http://dx.doi.org/10.1038/s41467-018-07653-5

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