Pharmacokinetics and Abuse Potential of Benzhydrocodone, a Novel Prodrug of Hydrocodone, After Intranasal Administration in Recreational Drug Users

OBJECTIVE: Developing an acetaminophen-free, immediate-release hydrocodone product remains an unmet medical need; however, new opioid analgesics should not introduce new abuse risks. Benzhydrocodone is a prodrug of hydrocodone that must be metabolized into hydrocodone by enzymes in the intestinal tr...

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Detalles Bibliográficos
Autores principales: Mickle, Travis C, Guenther, Sven M, Barrett, Andrew C, Roupe, Kathryn Ann, Zhou, Jing, Dickerson, Daniel, Webster, Lynn R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294406/
https://www.ncbi.nlm.nih.gov/pubmed/29092079
http://dx.doi.org/10.1093/pm/pnx247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294406/
https://www.ncbi.nlm.nih.gov/pubmed/29092079
http://dx.doi.org/10.1093/pm/pnx247

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