27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

Hypercholesterolemia is a risk factor for neurodegenerative diseases, but how high blood cholesterol levels are linked to neurodegeneration is still unknown. Here, we show that an excess of the blood–brain barrier permeable cholesterol metabolite 27-hydroxycholesterol (27-OH) impairs neuronal morpho...

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Detalles Bibliográficos
Autores principales: Merino-Serrais, Paula, Loera-Valencia, Raul, Rodriguez-Rodriguez, Patricia, Parrado-Fernandez, Cristina, Ismail, Muhammad A, Maioli, Silvia, Matute, Eduardo, Jimenez-Mateos, Eva Maria, Björkhem, Ingemar, DeFelipe, Javier, Cedazo-Minguez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294414/
https://www.ncbi.nlm.nih.gov/pubmed/30395175
http://dx.doi.org/10.1093/cercor/bhy274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294414/
https://www.ncbi.nlm.nih.gov/pubmed/30395175
http://dx.doi.org/10.1093/cercor/bhy274

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