Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks

Recent studies suggest that transcription takes place at DNA double-strand breaks (DSBs), that transcripts at DSBs are processed by Drosha and Dicer into damage-induced small RNAs (diRNAs), and that diRNAs are required for DNA repair. However, diRNAs have been mostly detected in reporter constructs...

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Detalles Bibliográficos
Autores principales: Bonath, Franziska, Domingo-Prim, Judit, Tarbier, Marcel, Friedländer, Marc R, Visa, Neus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294500/
https://www.ncbi.nlm.nih.gov/pubmed/30418607
http://dx.doi.org/10.1093/nar/gky1107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294500/
https://www.ncbi.nlm.nih.gov/pubmed/30418607
http://dx.doi.org/10.1093/nar/gky1107

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