Tethered imidazole mediated duplex stabilization and its potential for aptamer stabilization

Previous investigations of the impact of an imidazole-tethered thymidine in synthetic DNA duplexes, monitored using UV and NMR spectroscopy, revealed a base context dependent increase in thermal stability of these duplexes and a striking correlation with the imidazolium pK(a). Unrestrained molecular...

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Detalles Bibliográficos
Autores principales: Verdonck, Lars, Buyst, Dieter, de Vries, Anne-Mare, Gheerardijn, Vicky, Madder, Annemieke, Martins, José C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294506/
https://www.ncbi.nlm.nih.gov/pubmed/30418582
http://dx.doi.org/10.1093/nar/gky1062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294506/
https://www.ncbi.nlm.nih.gov/pubmed/30418582
http://dx.doi.org/10.1093/nar/gky1062

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