Cargando…

Computational insights into the mutagenicity of two tobacco-derived carcinogenic DNA lesions

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a potent carcinogen found in all tobacco products that leads to a variety of DNA lesions in cells, including O6-[4-oxo-4-(3-pyridyl)butyl]guanine (POB-G) and O6-[4-hydroxy-4-(3-pyridyl)butyl]guanine (PHB-G), which differ by only a single substituent...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Katie A, Garden, Josh L, Wetmore, Natasha T, Wetmore, Stacey D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294509/
https://www.ncbi.nlm.nih.gov/pubmed/30407571
http://dx.doi.org/10.1093/nar/gky1071