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Computational insights into the mutagenicity of two tobacco-derived carcinogenic DNA lesions

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a potent carcinogen found in all tobacco products that leads to a variety of DNA lesions in cells, including O6-[4-oxo-4-(3-pyridyl)butyl]guanine (POB-G) and O6-[4-hydroxy-4-(3-pyridyl)butyl]guanine (PHB-G), which differ by only a single substituent...

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Detalles Bibliográficos
Autores principales:	Wilson, Katie A, Garden, Josh L, Wetmore, Natasha T, Wetmore, Stacey D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294509/ https://www.ncbi.nlm.nih.gov/pubmed/30407571 http://dx.doi.org/10.1093/nar/gky1071

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