Structural basis for DNA break recognition by ARTD2/PARP2

Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and other proteins, initiating a cascade of events leading to DNA repair. In contrast to ARTD1, the founding member of the enzyme family, ARTD2 d...

Descripción completa

Detalles Bibliográficos
Autores principales: Obaji, Ezeogo, Haikarainen, Teemu, Lehtiö, Lari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294510/
https://www.ncbi.nlm.nih.gov/pubmed/30321391
http://dx.doi.org/10.1093/nar/gky927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294510/
https://www.ncbi.nlm.nih.gov/pubmed/30321391
http://dx.doi.org/10.1093/nar/gky927

Ejemplares similares