Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer

Despite aptamers are very promising alternative to antibodies, very few of them are under clinical trials or are used as drugs. Among them, NU172 is currently in Phase II as anticoagulant in heart disease treatments. It inhibits thrombin activity much more effectively than TBA, the best-known thromb...

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Detalles Bibliográficos
Autores principales: Troisi, Romualdo, Napolitano, Valeria, Spiridonova, Vera, Russo Krauss, Irene, Sica, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294562/
https://www.ncbi.nlm.nih.gov/pubmed/30357392
http://dx.doi.org/10.1093/nar/gky990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294562/
https://www.ncbi.nlm.nih.gov/pubmed/30357392
http://dx.doi.org/10.1093/nar/gky990

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