Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9–1–1 complex in the maintenance of the plastic genome of Leishmania

Leishmania species are protozoan parasites whose remarkably plastic genome limits the establishment of effective genetic manipulation and leishmaniasis treatment. The strategies used by Leishmania to maintain its genome while allowing variability are not fully understood. Here, we used DiCre-mediate...

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Detalles Bibliográficos
Autores principales: Damasceno, Jeziel D, Obonaga, Ricardo, Silva, Gabriel L A, Reis-Cunha, João L, Duncan, Samuel M, Bartholomeu, Daniella C, Mottram, Jeremy C, McCulloch, Richard, Tosi, Luiz R O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294564/
https://www.ncbi.nlm.nih.gov/pubmed/30380080
http://dx.doi.org/10.1093/nar/gky1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294564/
https://www.ncbi.nlm.nih.gov/pubmed/30380080
http://dx.doi.org/10.1093/nar/gky1017

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