Flexibility and structure of flanking DNA impact transcription factor affinity for its core motif

Spatial and temporal expression of genes is essential for maintaining phenotype integrity. Transcription factors (TFs) modulate expression patterns by binding to specific DNA sequences in the genome. Along with the core binding motif, the flanking sequence context can play a role in DNA–TF recogniti...

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Detalles Bibliográficos
Autores principales: Yella, Venkata Rajesh, Bhimsaria, Devesh, Ghoshdastidar, Debostuti, Rodríguez-Martínez, José A, Ansari, Aseem Z, Bansal, Manju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294565/
https://www.ncbi.nlm.nih.gov/pubmed/30395339
http://dx.doi.org/10.1093/nar/gky1057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294565/
https://www.ncbi.nlm.nih.gov/pubmed/30395339
http://dx.doi.org/10.1093/nar/gky1057

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