Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear

Aging is the leading risk factor for idiopathic Alzheimer’s disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates. In AD, neurofibrillary tangles (NFTs) appear first in entorhinal cortex, implying that aging processe...

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Autores principales: Gant, John C., Kadish, Inga, Chen, Kuey-Chu, Thibault, Olivier, Blalock, Eric M., Porter, Nada M., Landfield, Philip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294592/
https://www.ncbi.nlm.nih.gov/pubmed/30412490
http://dx.doi.org/10.3233/JAD-180618
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author Gant, John C.
Kadish, Inga
Chen, Kuey-Chu
Thibault, Olivier
Blalock, Eric M.
Porter, Nada M.
Landfield, Philip W.
author_facet Gant, John C.
Kadish, Inga
Chen, Kuey-Chu
Thibault, Olivier
Blalock, Eric M.
Porter, Nada M.
Landfield, Philip W.
author_sort Gant, John C.
collection PubMed
description Aging is the leading risk factor for idiopathic Alzheimer’s disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates. In AD, neurofibrillary tangles (NFTs) appear first in entorhinal cortex, implying that aging processes in entorhinal neurons promote NFT pathogenesis. Using electrophysiology and immunohistochemistry, we find pronounced aging-related Ca(2 +) dysregulation in rat entorhinal neurons homologous with the human neurons in which NFTs originate. Considering that humans recapitulate many aspects of animal brain aging, these results support the hypothesis that aging-related Ca(2 +) dysregulation occurs in human entorhinal neurons and promotes NFT pathogenesis.
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spelling pubmed-62945922018-12-18 Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear Gant, John C. Kadish, Inga Chen, Kuey-Chu Thibault, Olivier Blalock, Eric M. Porter, Nada M. Landfield, Philip W. J Alzheimers Dis Short Communication Aging is the leading risk factor for idiopathic Alzheimer’s disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates. In AD, neurofibrillary tangles (NFTs) appear first in entorhinal cortex, implying that aging processes in entorhinal neurons promote NFT pathogenesis. Using electrophysiology and immunohistochemistry, we find pronounced aging-related Ca(2 +) dysregulation in rat entorhinal neurons homologous with the human neurons in which NFTs originate. Considering that humans recapitulate many aspects of animal brain aging, these results support the hypothesis that aging-related Ca(2 +) dysregulation occurs in human entorhinal neurons and promotes NFT pathogenesis. IOS Press 2018-12-12 /pmc/articles/PMC6294592/ /pubmed/30412490 http://dx.doi.org/10.3233/JAD-180618 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Gant, John C.
Kadish, Inga
Chen, Kuey-Chu
Thibault, Olivier
Blalock, Eric M.
Porter, Nada M.
Landfield, Philip W.
Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title_full Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title_fullStr Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title_full_unstemmed Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title_short Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear
title_sort aging-related calcium dysregulation in rat entorhinal neurons homologous with the human entorhinal neurons in which alzheimer’s disease neurofibrillary tangles first appear
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294592/
https://www.ncbi.nlm.nih.gov/pubmed/30412490
http://dx.doi.org/10.3233/JAD-180618
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