Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability

The polyglutamine (polyQ) diseases, such as Huntington’s disease and the spinocerebellar ataxias, are characterized by the accumulation of elongated polyQ sequences (epolyQ) and mostly occur during midlife. Considering that polyQ disorders have not been selected out in evolution, there might be impo...

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Detalles Bibliográficos
Autores principales: Hashimoto, Makoto, Ho, Gilbert, Takamatsu, Yoshiki, Wada, Ryoko, Sugama, Shuei, Takenouchi, Takato, Masliah, Eliezer, Waragai, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294593/
https://www.ncbi.nlm.nih.gov/pubmed/30372687
http://dx.doi.org/10.3233/JHD-180309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294593/
https://www.ncbi.nlm.nih.gov/pubmed/30372687
http://dx.doi.org/10.3233/JHD-180309

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