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Shear-Induced Amyloid Formation in the Brain: IV. Effects on Synapses Surrounding Senile Plaque and in Plaque-Free Regions
Amyloid-β oligomers (AβO) have been proposed as neurotoxins in the synaptic dysfunction that precedes Alzheimer’s disease symptoms. Human and animal model studies report that senile plaques contain a halo of AβO molecules surrounding these plaques. A far smaller number of oligomers are distributed w...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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IOS Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294594/ https://www.ncbi.nlm.nih.gov/pubmed/30223395 http://dx.doi.org/10.3233/JAD-171080 |