Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose...

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Detalles Bibliográficos
Autores principales: Mcilroy, George D., Mitchell, Sharon E., Han, Weiping, Delibegović, Mirela, Rochford, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294754/
https://www.ncbi.nlm.nih.gov/pubmed/30552349
http://dx.doi.org/10.1038/s41598-018-36078-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294754/
https://www.ncbi.nlm.nih.gov/pubmed/30552349
http://dx.doi.org/10.1038/s41598-018-36078-9

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