Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1β and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11 trigger this regulated form of necrosis by cleavi...

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Detalles Bibliográficos
Autores principales: de Vasconcelos, Nathalia M., Van Opdenbosch, Nina, Van Gorp, Hanne, Parthoens, Eef, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294780/
https://www.ncbi.nlm.nih.gov/pubmed/29666477
http://dx.doi.org/10.1038/s41418-018-0106-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294780/
https://www.ncbi.nlm.nih.gov/pubmed/29666477
http://dx.doi.org/10.1038/s41418-018-0106-7

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