Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

PIEZO1 is a cation channel that is activated by mechanical forces such as fluid shear stress or membrane stretch. PIEZO1 loss-of-function mutations in patients are associated with congenital lymphedema with pleural effusion. However, the mechanistic link between PIEZO1 function and the development o...

Descripción completa

Detalles Bibliográficos
Autores principales: Nonomura, Keiko, Lukacs, Viktor, Sweet, Daniel T., Goddard, Lauren M., Kanie, Akemi, Whitwam, Tess, Ranade, Sanjeev S., Fujimori, Toshihiko, Kahn, Mark L., Patapoutian, Ardem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294938/
https://www.ncbi.nlm.nih.gov/pubmed/30482854
http://dx.doi.org/10.1073/pnas.1817070115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294938/
https://www.ncbi.nlm.nih.gov/pubmed/30482854
http://dx.doi.org/10.1073/pnas.1817070115

Ejemplares similares