Cargando…

Molecular structure of the ATP-bound, phosphorylated human CFTR

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel important in maintaining proper functions of the lung, pancreas, and intestine. The activity of CFTR is regulated by ATP and protein kinase A-dependent phosphorylation. To understand the conformational changes elicite...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhe, Liu, Fangyu, Chen, Jue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294961/ https://www.ncbi.nlm.nih.gov/pubmed/30459277 http://dx.doi.org/10.1073/pnas.1815287115

Ejemplares similares

Molecular structure of human KATP in complex with ATP and ADP
por: Lee, Kenneth Pak Kin, et al.
Publicado: (2017)

CFTR Gating I: Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)
por: Bompadre, Silvia G., et al.
Publicado: (2005)

Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
por: Mihályi, Csaba, et al.
Publicado: (2020)

Structure of a mitochondrial ATP synthase with bound native cardiolipin
por: Mühleip, Alexander, et al.
Publicado: (2019)

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells
por: Luz, Simão, et al.
Publicado: (2014)

Molecular structures of the eukaryotic retinal importer ABCA4
por: Liu, Fangyu, et al.
Publicado: (2021)

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy
por: Peng, Shuman, et al.
Publicado: (2023)

Structures and mechanisms of actin ATP hydrolysis
por: Kanematsu, Yusuke, et al.
Publicado: (2022)

Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding
por: Cheng, Meng-Ting, et al.
Publicado: (2022)

Structure of IMPORTIN-4 bound to the H3–H4–ASF1 histone–histone chaperone complex
por: Bernardes, Natália Elisa, et al.
Publicado: (2022)

Structure-based discovery of CFTR potentiators and inhibitors
por: Liu, Fangyu, et al.
Publicado: (2023)

Structure of the dimeric ATP synthase from bovine mitochondria
por: Spikes, Tobias E., et al.
Publicado: (2020)

Cryo-EM structure of the human chemerin receptor 1–Gi protein complex bound to the C-terminal nonapeptide of chemerin
por: Wang, Junlin, et al.
Publicado: (2023)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
por: Fei, Xue, et al.
Publicado: (2020)

Molecular Structures Reveal Synergistic Rescue of Δ508 CFTR by Trikafta Modulators
por: Fiedorczuk, Karol, et al.
Publicado: (2022)

Structure of Gcn1 bound to stalled and colliding 80S ribosomes
por: Pochopien, Agnieszka A., et al.
Publicado: (2021)

Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction
por: De Bei, Omar, et al.
Publicado: (2022)

Assembly of the peripheral stalk of ATP synthase in human mitochondria
por: He, Jiuya, et al.
Publicado: (2020)

ATP synthesis in an ancient ATP synthase at low driving forces
por: Litty, Dennis, et al.
Publicado: (2022)

Structures of mycobacterial ATP synthase bound to inhibitors
por: Courbon, Gautier M., et al.
Publicado: (2022)

Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle
por: Srivastava, Atul K., et al.
Publicado: (2022)

Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP
por: Li, Mufeng, et al.
Publicado: (2019)

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
por: Langer, Lukas M, et al.
Publicado: (2020)

Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions
por: Sorum, Ben, et al.
Publicado: (2017)

Structural evidence for the roles of divalent cations in actin polymerization and activation of ATP hydrolysis
por: Scipion, Clement P. M., et al.
Publicado: (2018)

Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis
por: Montgomery, Martin G., et al.
Publicado: (2021)

Human T cells recognize HLA-DP–bound peptides in two orientations
por: Klobuch, Sebastian, et al.
Publicado: (2022)

Vascular K(ATP) channel structural dynamics reveal regulatory mechanism by Mg-nucleotides
por: Sung, Min Woo, et al.
Publicado: (2021)

Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein
por: Jeoung, Jae-Hun, et al.
Publicado: (2022)

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA
por: Zheng, Fengwei, et al.
Publicado: (2020)

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome
por: Rahman, Sanim, et al.
Publicado: (2022)

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
por: Manolaridis, Ioannis, et al.
Publicado: (2018)

Structural basis for heme detoxification by an ATP-binding cassette–type efflux pump in gram-positive pathogenic bacteria
por: Nakamura, Hiro, et al.
Publicado: (2022)

Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain
por: Cook, Jonathan, et al.
Publicado: (2020)

Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family
por: Hart, Kaitlin N., et al.
Publicado: (2021)

On the Mechanism of MgATP-dependent Gating of CFTR Cl(−) Channels
por: Vergani, Paola, et al.
Publicado: (2003)

Regulation of CFTR Cl- channel gating by ADP and ATP analogues
Publicado: (1995)

Ultrafast photooxidation of protein-bound anionic flavin radicals
por: Zhuang, Bo, et al.
Publicado: (2022)

Structures of the peptidase-containing ABC transporter PCAT1 under equilibrium and nonequilibrium conditions
por: Kieuvongngam, Virapat, et al.
Publicado: (2022)

Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes
por: Yu, You, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qbivncfqfpflcinb9hie13fls4