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Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC

OBJECTIVE: Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrP(C)) into a pathogenic form (PrP(Sc)) that accumulates in the brain and lymphatic tissue. A...

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Detalles Bibliográficos
Autores principales: Hwang, Soyoun, Tatum, Trudy, Lebepe-Mazur, Semakaleng, Nicholson, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295004/
https://www.ncbi.nlm.nih.gov/pubmed/30547851
http://dx.doi.org/10.1186/s13104-018-3982-5