Toxicity of overexpressed MeCP2 is independent of HDAC3 activity

Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses wild-type or mutated MeCP2 from the Mapt (Tau) loc...

Descripción completa

Detalles Bibliográficos
Autores principales: Koerner, Martha V., FitzPatrick, Laura, Selfridge, Jim, Guy, Jacky, De Sousa, Dina, Tillotson, Rebekah, Kerr, Alastair, Sun, Zheng, Lazar, Mitchell A., Lyst, Matthew J., Bird, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295171/
https://www.ncbi.nlm.nih.gov/pubmed/30463906
http://dx.doi.org/10.1101/gad.320325.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295171/
https://www.ncbi.nlm.nih.gov/pubmed/30463906
http://dx.doi.org/10.1101/gad.320325.118

Ejemplares similares