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The in vivo dsRNA Cleavage Has Sequence Preference in Insects

Exogenous dsRNA enters the insect body and can induce the RNAi effect only when it is cleaved into siRNA. However, what kinds of base composition are easier to cut and what kinds of siRNA will be produced in vivo is largely unknown. In this study, we found that dsRNA processing into siRNA has sequen...

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Detalles Bibliográficos
Autores principales: Guan, Ruobing, Hu, Shaoru, Li, Haichao, Shi, Zhenying, Miao, Xuexia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295558/
https://www.ncbi.nlm.nih.gov/pubmed/30618790
http://dx.doi.org/10.3389/fphys.2018.01768