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On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory

Piperlongumine (PL) is an anticancer compound whose activity is related to the inhibition of human glutathione transferase of pi class (GSTP1) overexpressed in cancerous tumors and implicated in the metabolism of electrophilic compounds. In the present work, the inhibition mechanism of hydrolyzed pi...

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Detalles Bibliográficos
Autores principales: Prejanò, Mario, Marino, Tiziana, Russo, Nino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296316/
https://www.ncbi.nlm.nih.gov/pubmed/30619815
http://dx.doi.org/10.3389/fchem.2018.00606