Exploring the insulin secretory properties of the PGD(2)-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients

AIMS/HYPOTHESIS: GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D(2) (PGD(2)) and it is enriched in human islets. In rodent islets, PGD(2) is produced in response to glucose, suggesting that the PGD(2)-GPR44/DP2 axis may play a role in human islet function...

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Detalles Bibliográficos
Autores principales: Skrtic, Stanko, Tyrberg, Björn, Broberg, Malin, Ericsson, Hans, Schnecke, Volker, Kjaer, Magnus, Hompesch, Marcus, Andersson, Eva-Marie, Ryberg, Erik, Aivazidis, Alexander, Wennberg Huldt, Charlotte, Löfgren, Lars, Morrow, Linda, Parkinson, Joanna, Rydén-Bergsten, Tina, Watkins, Elaine, Sörhede Winzell, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296667/
https://www.ncbi.nlm.nih.gov/pubmed/30557325
http://dx.doi.org/10.1371/journal.pone.0208998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296667/
https://www.ncbi.nlm.nih.gov/pubmed/30557325
http://dx.doi.org/10.1371/journal.pone.0208998

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