The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon...

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Detalles Bibliográficos
Autores principales: Nishi, Ryotaro, Wijnhoven, Paul W. G., Kimura, Yusuke, Matsui, Misaki, Konietzny, Rebecca, Wu, Qian, Nakamura, Keisuke, Blundell, Tom L., Kessler, Benedikt M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297141/
https://www.ncbi.nlm.nih.gov/pubmed/30559450
http://dx.doi.org/10.1038/s41598-018-36235-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297141/
https://www.ncbi.nlm.nih.gov/pubmed/30559450
http://dx.doi.org/10.1038/s41598-018-36235-0

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