Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show here that cells can respond to protease/substrate imbalance in this compartment by de novo expression of multiple lysosomal hydrolases. This res...

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Detalles Bibliográficos
Autores principales: Martínez-Fábregas, Jonathan, Prescott, Alan, van Kasteren, Sander, Pedrioli, Deena Leslie, McLean, Irwin, Moles, Anna, Reinheckel, Thomas, Poli, Valeria, Watts, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297226/
https://www.ncbi.nlm.nih.gov/pubmed/30559339
http://dx.doi.org/10.1038/s41467-018-07741-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297226/
https://www.ncbi.nlm.nih.gov/pubmed/30559339
http://dx.doi.org/10.1038/s41467-018-07741-6

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