The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers. Intra-chromosomal DNA double-strand break (DSB) joining events during immunoglobulin class switch recombination (CSR) require 53BP1. However, in BRCA...

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Detalles Bibliográficos
Autores principales: Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297349/
https://www.ncbi.nlm.nih.gov/pubmed/30559443
http://dx.doi.org/10.1038/s41467-018-07855-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297349/
https://www.ncbi.nlm.nih.gov/pubmed/30559443
http://dx.doi.org/10.1038/s41467-018-07855-x

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