Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

BACKGROUND: The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reser...

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Detalles Bibliográficos
Autores principales: Anderson, Brett D., Ikeda, Terumasa, Moghadasi, Seyed Arad, Martin, Amber St., Brown, William L., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297987/
https://www.ncbi.nlm.nih.gov/pubmed/30558640
http://dx.doi.org/10.1186/s12977-018-0459-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297987/
https://www.ncbi.nlm.nih.gov/pubmed/30558640
http://dx.doi.org/10.1186/s12977-018-0459-5

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