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GrandPrix: scaling up the Bayesian GPLVM for single-cell data

MOTIVATION: The Gaussian Process Latent Variable Model (GPLVM) is a popular approach for dimensionality reduction of single-cell data and has been used for pseudotime estimation with capture time information. However, current implementations are computationally intensive and will not scale up to mod...

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Detalles Bibliográficos
Autores principales: Ahmed, Sumon, Rattray, Magnus, Boukouvalas, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298059/
https://www.ncbi.nlm.nih.gov/pubmed/30561544
http://dx.doi.org/10.1093/bioinformatics/bty533