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Dual coding potential of a 2′,5′-branched ribonucleotide in DNA

Branchpoints in RNA templates are highly mutagenic, but it is not known yet whether this also applies to branchpoints in DNA templates. Here, we report how nucleic acid polymerases replicate a 2′,5′-branched DNA (bDNA) molecule. We constructed long-chained bDNA templates containing a branch guanosin...

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Detalles Bibliográficos
Autores principales: Döring, Jessica, Hurek, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298571/
https://www.ncbi.nlm.nih.gov/pubmed/30361268
http://dx.doi.org/10.1261/rna.068486.118