Influence of Mg(2+) on the conformational flexibility of a tetracycline aptamer

The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibiotic tetracycline (TC) with exceptionally high affinity. Although a crystal structure exists of the TC-bound state, little is known about the conformational dynamics and changes upon ligand binding. In t...

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Detalles Bibliográficos
Autores principales: Hetzke, Thilo, Vogel, Marc, Gophane, Dnyaneshwar B., Weigand, Julia E., Suess, Beatrix, Sigurdsson, Snorri Th., Prisner, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298572/
https://www.ncbi.nlm.nih.gov/pubmed/30337459
http://dx.doi.org/10.1261/rna.068684.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298572/
https://www.ncbi.nlm.nih.gov/pubmed/30337459
http://dx.doi.org/10.1261/rna.068684.118

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