MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

α-Ketoglutarate (αKG) is a key node in many important metabolic pathways. The αKG analogue N-oxalylglycine (NOG) and its cell-permeable pro-drug dimethyloxalylglycine (DMOG) are extensively used to inhibit αKG-dependent dioxygenases. However, whether NOG interference with other αKG-dependent process...

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Detalles Bibliográficos
Autores principales: Fets, Louise, Driscoll, Paul C., Grimm, Fiona, Jain, Aakriti, Nunes, Patrícia M., Gounis, Michalis, Doglioni, Ginevra, Papageorgiou, George, Ragan, Timothy J., Campos, Sebastien, Silva dos Santos, Mariana, MacRae, James I., O’Reilly, Nicola, Wright, Alan J., Benes, Cyril H., Courtney, Kevin D., House, David, Anastasiou, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298574/
https://www.ncbi.nlm.nih.gov/pubmed/30297875
http://dx.doi.org/10.1038/s41589-018-0136-y

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