Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Microarray technology fails in detecting point mutations present in a small fraction of cells from heterogeneous tissue samples or in plasma in a background of wild-type cell-free circulating tumor DNA (ctDNA). The aim of this study is to overcome the lack of sensitivity and specificity of current m...

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Detalles Bibliográficos
Autores principales: Damin, Francesco, Galbiati, Silvia, Soriani, Nadia, Burgio, Valentina, Ronzoni, Monica, Ferrari, Maurizio, Chiari, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298683/
https://www.ncbi.nlm.nih.gov/pubmed/30562355
http://dx.doi.org/10.1371/journal.pone.0207876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298683/
https://www.ncbi.nlm.nih.gov/pubmed/30562355
http://dx.doi.org/10.1371/journal.pone.0207876

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