Cargando…

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly distinct from all other T cell populations in the thymus in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gegonne, Anne, Chen, Qing-Rong, Dey, Anup, Etzensperger, Ruth, Tai, Xuguang, Singer, Alfred, Meerzaman, Daoud, Ozato, Keiko, Singer, Dinah S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298745/ https://www.ncbi.nlm.nih.gov/pubmed/29972774 http://dx.doi.org/10.1016/j.celrep.2018.06.007

Ejemplares similares

BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin
por: Devaiah, Ballachanda N., et al.
Publicado: (2016)

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses
por: Dey, Anup, et al.
Publicado: (2019)

T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus
por: Punt, Jennifer A., et al.
Publicado: (1997)

How autoreactive thymocytes differentiate into regulatory versus effector CD4(+) T cells after avoiding clonal deletion
por: Tai, Xuguang, et al.
Publicado: (2023)

Identification of lineage-specifying cytokines that signal all CD8-cytotoxic lineage fate decisions in the thymus
por: Etzensperger, Ruth, et al.
Publicado: (2017)

Activation of JNK Triggers Release of Brd4 from Mitotic Chromosomes and Mediates Protection from Drug-Induced Mitotic Stress
por: Nishiyama, Akira, et al.
Publicado: (2012)

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
por: Pobezinsky, Leonid A., et al.
Publicado: (2012)

Cohesin regulates alternative splicing
por: Singh, Amit K., et al.
Publicado: (2023)

The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis
por: Cheng, Dan, et al.
Publicado: (2021)

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)
por: Ashe, Jennifer M., et al.
Publicado: (1999)

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression
por: Inamochi, Yuko, et al.
Publicado: (2016)

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks
por: Bhandoola, Avinash, et al.
Publicado: (2000)

Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
por: Suzuki, Harumi, et al.
Publicado: (1997)

Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential
por: Oh, Seungyoul, et al.
Publicado: (2023)

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
por: Lee, Ji-Eun, et al.
Publicado: (2017)

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus
por: McCaughtry, Tom M., et al.
Publicado: (2012)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
por: Erman, Batu, et al.
Publicado: (2004)

Coreceptor gene imprinting governs thymocyte lineage fate
por: Adoro, Stanley, et al.
Publicado: (2012)

E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex
por: Kadakia, Tejas, et al.
Publicado: (2019)

BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene
por: Sakurai, Naoko, et al.
Publicado: (2017)

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status
Publicado: (1993)

Editorial: BET proteins in chromatin architecture, transcription and disease
por: Singh, Amit Kumar, et al.
Publicado: (2022)

Preferential expression of fibronectin receptors on immature thymocytes
Publicado: (1988)

Murine T-Lymphomas Corresponding to the Immature CD4(-)8(+) Thymocyte Subset
por: Richie, Ellen R., et al.
Publicado: (1991)

MYC protein stability is negatively regulated by BRD4
por: Devaiah, Ballachanda N., et al.
Publicado: (2020)

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4(+)CD8(+) Thymocytes
por: Rincón, Mercedes, et al.
Publicado: (1998)

The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains
por: Weissman, Jocelyn D., et al.
Publicado: (2021)

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8(+) T Cells
por: Yu, Qing, et al.
Publicado: (2003)

Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes
Publicado: (1996)

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
Publicado: (1993)

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
por: Milner, J. Justin, et al.
Publicado: (2021)

DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner
por: Song, Yawei, et al.
Publicado: (2020)

Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Major histocompatibility complex-restricted and -unrestricted B cell responses are mediated by distinct B cell subpopulations
por: Asano, Y, et al.
Publicado: (1981)

c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
por: Hu, Taishan, et al.
Publicado: (2010)

The molecular jury: deciding whether immature thymocytes should live or die
Publicado: (1996)

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
por: Yu, Qing, et al.
Publicado: (2006)

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
Publicado: (1989)

Immature CD4(+)CD8(+) Thymocytes Are Preferentially Infected by Measles Virus in Human Thymic Organ Cultures
por: Okamoto, Yukari, et al.
Publicado: (2012)

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro
Publicado: (1990)

Activated α4 Integrins are Preferentially Expressed on Immature Thymocytes and Activated T Cells
por: Shu, Fengyu, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_5bjt2rcpsaeu9lejjr8ngquofo