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Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contributio...

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Detalles Bibliográficos
Autores principales: Säwen, Petter, Eldeeb, Mohamed, Erlandsson, Eva, Kristiansen, Trine A, Laterza, Cecilia, Kokaia, Zaal, Karlsson, Göran, Yuan, Joan, Soneji, Shamit, Mandal, Pankaj K, Rossi, Derrick J, Bryder, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298771/
https://www.ncbi.nlm.nih.gov/pubmed/30561324
http://dx.doi.org/10.7554/eLife.41258