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The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

The E. coli ribosome exit tunnel can accommodate small folded proteins, while larger ones fold outside. It remains unclear, however, to what extent the geometry of the tunnel influences protein folding. Here, using E. coli ribosomes with deletions in loops in proteins uL23 and uL24 that protrude int...

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Detalles Bibliográficos
Autores principales: Kudva, Renuka, Tian, Pengfei, Pardo-Avila, Fátima, Carroni, Marta, Best, Robert B, Bernstein, Harris D, von Heijne, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298777/
https://www.ncbi.nlm.nih.gov/pubmed/30475203
http://dx.doi.org/10.7554/eLife.36326