Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of Met-tRNA(i) in a ‘P(IN)’ state, which is antagonized by the factor eIF1. eIF5 is a GTPase activating protein (GAP) of eIF2 that additionally promotes stringent AUG selection, but the molecular basis of its du...

Descripción completa

Detalles Bibliográficos
Autores principales: Llácer, Jose Luis, Hussain, Tanweer, Saini, Adesh K, Nanda, Jagpreet Singh, Kaur, Sukhvir, Gordiyenko, Yuliya, Kumar, Rakesh, Hinnebusch, Alan G, Lorsch, Jon R, Ramakrishnan, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298780/
https://www.ncbi.nlm.nih.gov/pubmed/30475211
http://dx.doi.org/10.7554/eLife.39273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298780/
https://www.ncbi.nlm.nih.gov/pubmed/30475211
http://dx.doi.org/10.7554/eLife.39273

Ejemplares similares