A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis

Interfering with interactions of vascular endothelial growth factors (VEGFs) with their receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an antagonist peptide of VEGF-A and VEGF-B reproducing two discontinuous receptor binding regions of VEGF-B (loop 1 and loop3) co...

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Detalles Bibliográficos
Autores principales: Farzaneh Behelgardi, Maryam, Zahri, Saber, Mashayekhi, Farhad, Mansouri, Kamran, Asghari, S. Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298961/
https://www.ncbi.nlm.nih.gov/pubmed/30560942
http://dx.doi.org/10.1038/s41598-018-36394-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298961/
https://www.ncbi.nlm.nih.gov/pubmed/30560942
http://dx.doi.org/10.1038/s41598-018-36394-0

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