Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2

Mutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhaliwal, Jagroop, Kannangara, Timal S., Vaculik, Michael, Xue, Yingben, Kumar, Keren L., Maione, Amanda, Béïque, Jean-Claude, Shen, Jie, Lagace, Diane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299003/
https://www.ncbi.nlm.nih.gov/pubmed/30560948
http://dx.doi.org/10.1038/s41598-018-36363-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299003/
https://www.ncbi.nlm.nih.gov/pubmed/30560948
http://dx.doi.org/10.1038/s41598-018-36363-7

Ejemplares similares