Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2

Mutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this ef...

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Detalles Bibliográficos
Autores principales: Dhaliwal, Jagroop, Kannangara, Timal S., Vaculik, Michael, Xue, Yingben, Kumar, Keren L., Maione, Amanda, Béïque, Jean-Claude, Shen, Jie, Lagace, Diane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299003/
https://www.ncbi.nlm.nih.gov/pubmed/30560948
http://dx.doi.org/10.1038/s41598-018-36363-7

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