Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review

Bartonellosis is an infectious disease caused by Bartonella species that are distributed worldwide with animal and public health impact varying according to Bartonella species, infection phase, immunological characteristics, and geographical region. Bartonella is widely present in various mammals in...

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Autores principales: Deng, Hongkuan, Pang, Qiuxiang, Zhao, Bosheng, Vayssier-Taussat, Muriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299047/
https://www.ncbi.nlm.nih.gov/pubmed/30619777
http://dx.doi.org/10.3389/fcimb.2018.00431
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author Deng, Hongkuan
Pang, Qiuxiang
Zhao, Bosheng
Vayssier-Taussat, Muriel
author_facet Deng, Hongkuan
Pang, Qiuxiang
Zhao, Bosheng
Vayssier-Taussat, Muriel
author_sort Deng, Hongkuan
collection PubMed
description Bartonellosis is an infectious disease caused by Bartonella species that are distributed worldwide with animal and public health impact varying according to Bartonella species, infection phase, immunological characteristics, and geographical region. Bartonella is widely present in various mammals including cats, rodents, ruminants, and humans. At least 13 Bartonella species or subspecies are zoonotic. Each species has few reservoir animals in which it is often asymptomatic. Bartonella infection may lead to various clinical symptoms in humans. As described in the B.tribocorum-rat model, when Bartonella was seeded into the blood stream, they could escape immunity, adhered to and invaded host erythrocytes. They then replicated and persisted in the infected erythrocytes for several weeks. This review summarizes the current knowledge of how Bartonella prevent phagocytosis and complement activation, what pathogenesis factors are involved in erythrocyte adhesion and invasion, and how Bartonella could replicate and persist in mammalian erythrocytes. Current advances in research will help us to decipher molecular mechanisms of interactions between Bartonella and mammalian erythrocytes and may help in the development of biological strategies for the prevention and control of bartonellosis.
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spelling pubmed-62990472019-01-07 Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review Deng, Hongkuan Pang, Qiuxiang Zhao, Bosheng Vayssier-Taussat, Muriel Front Cell Infect Microbiol Cellular and Infection Microbiology Bartonellosis is an infectious disease caused by Bartonella species that are distributed worldwide with animal and public health impact varying according to Bartonella species, infection phase, immunological characteristics, and geographical region. Bartonella is widely present in various mammals including cats, rodents, ruminants, and humans. At least 13 Bartonella species or subspecies are zoonotic. Each species has few reservoir animals in which it is often asymptomatic. Bartonella infection may lead to various clinical symptoms in humans. As described in the B.tribocorum-rat model, when Bartonella was seeded into the blood stream, they could escape immunity, adhered to and invaded host erythrocytes. They then replicated and persisted in the infected erythrocytes for several weeks. This review summarizes the current knowledge of how Bartonella prevent phagocytosis and complement activation, what pathogenesis factors are involved in erythrocyte adhesion and invasion, and how Bartonella could replicate and persist in mammalian erythrocytes. Current advances in research will help us to decipher molecular mechanisms of interactions between Bartonella and mammalian erythrocytes and may help in the development of biological strategies for the prevention and control of bartonellosis. Frontiers Media S.A. 2018-12-12 /pmc/articles/PMC6299047/ /pubmed/30619777 http://dx.doi.org/10.3389/fcimb.2018.00431 Text en Copyright © 2018 Deng, Pang, Zhao and Vayssier-Taussat. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Deng, Hongkuan
Pang, Qiuxiang
Zhao, Bosheng
Vayssier-Taussat, Muriel
Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title_full Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title_fullStr Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title_full_unstemmed Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title_short Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review
title_sort molecular mechanisms of bartonella and mammalian erythrocyte interactions: a review
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299047/
https://www.ncbi.nlm.nih.gov/pubmed/30619777
http://dx.doi.org/10.3389/fcimb.2018.00431
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