SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen

Endoplasmic reticulum (ER) stress from accumulated misfolded proteins in the ER can activate the unfolded protein response (UPR). The UPR acts either to restore proteostasis or to activate cell death pathways if the stress cannot be resolved. The key downstream effectors in these pathways have been...

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Detalles Bibliográficos
Autores principales: Chidawanyika, Tamutenda, Sergison, Elizabeth, Cole, Michael, Mark, Kenneth, Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299087/
https://www.ncbi.nlm.nih.gov/pubmed/30588337
http://dx.doi.org/10.1038/s41420-018-0135-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299087/
https://www.ncbi.nlm.nih.gov/pubmed/30588337
http://dx.doi.org/10.1038/s41420-018-0135-5

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