Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel

By vacuolar patch-clamp and Ca(2+) imaging experiments, we show that the yeast vacuolar transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca(2+) and inhibited by Ca(2+) from the vacuolar lumen. The channel is cooperatively affected by vacuolar Ca(2+) (Hill coefficient, 1.5), su...

Descripción completa

Detalles Bibliográficos
Autores principales: Amini, Mahnaz, Wang, Hongmei, Belkacemi, Anouar, Jung, Martin, Bertl, Adam, Schlenstedt, Gabriel, Flockerzi, Veit, Beck, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299153/
https://www.ncbi.nlm.nih.gov/pubmed/30572205
http://dx.doi.org/10.1016/j.isci.2018.11.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299153/
https://www.ncbi.nlm.nih.gov/pubmed/30572205
http://dx.doi.org/10.1016/j.isci.2018.11.037

Ejemplares similares