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Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel
By vacuolar patch-clamp and Ca(2+) imaging experiments, we show that the yeast vacuolar transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca(2+) and inhibited by Ca(2+) from the vacuolar lumen. The channel is cooperatively affected by vacuolar Ca(2+) (Hill coefficient, 1.5), su...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299153/ https://www.ncbi.nlm.nih.gov/pubmed/30572205 http://dx.doi.org/10.1016/j.isci.2018.11.037 |