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Dichotomy in redundant enhancers points to presence of initiators of gene regulation

BACKGROUND: The regulatory landscape of a gene locus often consists of several functionally redundant enhancers establishing phenotypic robustness and evolutionary stability of its regulatory program. However, it is unclear what mechanisms are employed by redundant enhancers to cooperatively orchest...

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Detalles Bibliográficos
Autores principales: Song, Wei, Ovcharenko, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299655/
https://www.ncbi.nlm.nih.gov/pubmed/30563465
http://dx.doi.org/10.1186/s12864-018-5335-0