A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

BACKGROUND: The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity relation...

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Detalles Bibliográficos
Autores principales: Tang, Niansheng, Wang, Songjian, Ye, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299663/
https://www.ncbi.nlm.nih.gov/pubmed/30563454
http://dx.doi.org/10.1186/s12874-018-0604-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299663/
https://www.ncbi.nlm.nih.gov/pubmed/30563454
http://dx.doi.org/10.1186/s12874-018-0604-9

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