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Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores
We characterized a panel of cancer cells and found that they exhibited chromosome instability (CIN) that was associated with high frequencies of aberrant kinetochore:microtubule attachments. Failure to resolve these defective attachments before anaphase onset can lead to missegregation of chromosome...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300107/ https://www.ncbi.nlm.nih.gov/pubmed/30513041 http://dx.doi.org/10.1080/15384101.2018.1553340 |