Cargando…

Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant

Preventive HIV-1 vaccine strategies rely on the elicitation of broadly neutralizing antibody (bNAb) responses, but their induction in vivo by vaccination remains challenging. Considering that the ability of an epitope to elicit effective humoral immunity depends on its exposure on the virion, we hav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beltran-Pavez, Carolina, Ferreira, Carolina B., Merino-Mansilla, Alberto, Fabra-Garcia, Amanda, Casadella, Maria, Noguera-Julian, Marc, Paredes, Roger, Olvera, Alex, Haro, Isabel, Brander, Christian, Garcia, Felipe, Gatell, Jose M., Yuste, Eloisa, Sanchez-Merino, Victor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300218/ https://www.ncbi.nlm.nih.gov/pubmed/30566493 http://dx.doi.org/10.1371/journal.pone.0208345

Ejemplares similares

Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses
por: Beltran-Pavez, Carolina, et al.
Publicado: (2022)

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope
por: Aguado-Garcia, Diana, et al.
Publicado: (2022)

Induction of HIV Neutralizing Antibodies against the MPER of the HIV Envelope Protein by HA/gp41 Chimeric Protein-Based DNA and VLP Vaccines
por: Ye, Ling, et al.
Publicado: (2011)

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies
por: Rantalainen, Kimmo, et al.
Publicado: (2020)

Multimeric Scaffolds Displaying the HIV-1 Envelope MPER Induce MPER-Specific Antibodies and Cross-Neutralizing Antibodies when Co-Immunized with gp160 DNA
por: Krebs, Shelly J., et al.
Publicado: (2014)

Correction: Multimeric Scaffolds Displaying the HIV-1 Envelope MPER Induce MPER-Specific Antibodies and Cross-Neutralizing Antibodies when Co-Immunized with gp160 DNA
Publicado: (2015)

HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
por: Pernas, Maria, et al.
Publicado: (2015)

SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro
por: van der Veen, Daan R, et al.
Publicado: (2008)

Low levels of anti-MPER antibodies are detectable in viremic HIV infected
por: Carrillo, J, et al.
Publicado: (2012)

Co-Immunization With CHIKV VLP and DNA Vaccines Induces a Promising Humoral Response in Mice
por: Zhao, Zhimin, et al.
Publicado: (2021)

Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice
por: Ralph, Martin R., et al.
Publicado: (2021)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota
por: Borgognone, Alessandra, et al.
Publicado: (2022)

Immunogenic selection of HIV-1 MPER epitopes for improved vaccine design
por: Wieczorek, L, et al.
Publicado: (2012)

P05-06. Masking of MPER epitopes through self-associations
por: Strong, RK, et al.
Publicado: (2009)

Potentiating humoral and cellular immunity using a novel hybrid polymer-lipid nanoparticle adjuvant for HBsAg-VLP vaccine
por: Liu, Xuhan, et al.
Publicado: (2023)

Low-Replicating Viruses and Strong Anti-Viral Immune Response Associated with Prolonged Disease Control in a Superinfected HIV-1 LTNP Elite Controller
por: Pernas, María, et al.
Publicado: (2012)

Interaction between Borrelia miyamotoi variable major proteins Vlp15/16 and Vlp18 with plasminogen and complement
por: Schmidt, Frederik L., et al.
Publicado: (2021)

Turnip Mosaic Virus Coat Protein Deletion Mutants Allow Defining Dispensable Protein Domains for ‘in Planta’ eVLP Formation
por: Yuste-Calvo, Carmen, et al.
Publicado: (2020)

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro
por: Olvera, Alex, et al.
Publicado: (2018)

Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals
por: Molinos-Albert, Luis M, et al.
Publicado: (2014)

Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins
por: Zhang, Si Min, et al.
Publicado: (2015)

VLP-ELISA for the Detection of IgG Antibodies against Spike, Envelope, and Membrane Antigens of SARS-CoV-2 in Indian Population
por: Kumar, Dilip, et al.
Publicado: (2023)

On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP
por: Roldão, António, et al.
Publicado: (2012)

VLP‐factory™ and ADDomer(©): Self‐assembling Virus‐Like Particle (VLP) Technologies for Multiple Protein and Peptide Epitope Display
por: Sari‐Ak, Duygu, et al.
Publicado: (2021)

Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses
por: Yi, Guohua, et al.
Publicado: (2013)

Structural basis of antiviral activity of peptides from MPER of FIV gp36
por: Grimaldi, Manuela, et al.
Publicado: (2018)

The Structural and Immunological Properties of Chimeric Proteins Containing HIV-1 MPER Sites
por: Rudometov, A. P., et al.
Publicado: (2019)

RNA Phage VLP-Based Vaccine Platforms
por: Peabody, David S., et al.
Publicado: (2021)

Erythro-VLP: Erythrocyte Virus-Like-Particles
por: Himbert, Sebastian, et al.
Publicado: (2021)

Virus-like particle (VLP)-based vaccines for pandemic influenza: Performance of a VLP vaccine during the 2009 influenza pandemic
por: López-Macías, Constantino
Publicado: (2012)

LB18. An Enveloped Virus-like Particle (eVLP) Cytomegalovirus (CMV) Vaccine Is Immunogenic and Safe: Results of a First-in-Humans Study
por: Gantt, Soren, et al.
Publicado: (2018)

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels
por: Elizalde-Torrent, Aleix, et al.
Publicado: (2023)

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1
por: Ruprecht, Claudia R., et al.
Publicado: (2011)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2012)

Correction: Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses
por: Yi, Guohua, et al.
Publicado: (2013)

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
por: Carravilla, Pablo, et al.
Publicado: (2019)

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8
por: Soto, Cinque, et al.
Publicado: (2016)

An MPER antibody neutralizes HIV-1 using germline features shared among donors
por: Zhang, Lei, et al.
Publicado: (2019)

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
por: Schoeder, Clara T., et al.
Publicado: (2022)

Envelope filter sequence to delete blinks and overshoots
por: Merino, Manuel, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_uh8kdj4vhilf44m7fcgk9p0fag