Predicting protein targets for drug-like compounds using transcriptomics

An expanded chemical space is essential for improved identification of small molecules for emerging therapeutic targets. However, the identification of targets for novel compounds is biased towards the synthesis of known scaffolds that bind familiar protein families, limiting the exploration of chem...

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Detalles Bibliográficos
Autores principales: Pabon, Nicolas A., Xia, Yan, Estabrooks, Samuel K., Ye, Zhaofeng, Herbrand, Amanda K., Süß, Evelyn, Biondi, Ricardo M., Assimon, Victoria A., Gestwicki, Jason E., Brodsky, Jeffrey L., Camacho, Carlos J., Bar-Joseph, Ziv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300300/
https://www.ncbi.nlm.nih.gov/pubmed/30532261
http://dx.doi.org/10.1371/journal.pcbi.1006651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300300/
https://www.ncbi.nlm.nih.gov/pubmed/30532261
http://dx.doi.org/10.1371/journal.pcbi.1006651

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