NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Basal forebrain cholinergic neurons (BFCNs) depend on nerve growth factor (NGF) for their survival/differentiation and innervate cortical and hippocampal regions involved in memory/learning processes. Cholinergic hypofunction and/or degeneration early occurs at prodromal stages of Alzheimer’s diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Latina, Valentina, Caioli, Silvia, Zona, Cristina, Ciotti, Maria Teresa, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300588/
https://www.ncbi.nlm.nih.gov/pubmed/30618634
http://dx.doi.org/10.3389/fncel.2018.00487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300588/
https://www.ncbi.nlm.nih.gov/pubmed/30618634
http://dx.doi.org/10.3389/fncel.2018.00487

Ejemplares similares